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For menopausal women with the ApoE4 gene, focusing on specific nutrients can potentially lower dementia risk.  Omega-3 fatty acids, especially DHA found in cold water fish like salmon, are vital for brain health and inflammation control.  ApoE4 carriers may need more DHA due to their unique brain metabolism. Additionally, consider supplementing with phosphatidylcholine-DHA (PC-DHA) for improved access to the brain by these omega-3’s.

Antioxidants like quercetin in onions and capers, and resveratrol in red grapes, could reduce the activity of MMP-9, a protein where higher levels are implicated with increased inflammation in combination with ApoE4 and declining estrogen.

These strategies may also counteract disrupted brain sugar metabolism in ApoE4 carriers during menopause, supporting cognitive health.

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